BDBM501112 4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6- (((R)-3- hydroxypyrroli- din-1-yl)methyl)-5-((S)- tetrahydrofuran- 3-yl)pyridin-2- yl)amino)isoin- dolin-1-one::US11021481, Compound I-784::US11078201, Compound I-784::US11548890, Compound I-784

SMILES O[C@@H]1CCN(Cc2nc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)ccc2[C@@H]2CCOC2)C1

InChI Key InChIKey=JAJGIMSEYAGXJX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 501112   

LigandPNGBDBM501112(US11021481, Compound I-784 | 4-(7- fluoroimidazo [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501112(US11021481, Compound I-784 | 4-(7- fluoroimidazo [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM501112(US11021481, Compound I-784 | 4-(7- fluoroimidazo [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM501112(US11021481, Compound I-784 | 4-(7- fluoroimidazo [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM501112(US11021481, Compound I-784 | 4-(7- fluoroimidazo [...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent