BDBM50110826 CHEMBL3605972::US10800739, Compound (2)::US11420940, cpd (2)

SMILES NC(=O)c1cccc2CN(CCc3ccccc3)C(=O)c12

InChI Key InChIKey=QMFJNBILTNXCGW-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50110826   

TargetPoly [ADP-ribose] polymerase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd:  178nMAssay Description:Binding affinity to full length recombinant human PARP-2 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd:  32nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd: <30nMAssay Description:Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd:  180nMAssay Description:Preferably, for the screening method above cited, both the PARP protein and the 5H-phenanthridin-6-one-derived probe of formula (IP) are pre-mixed, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd: <30nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50110826(CHEMBL3605972 | US10800739, Compound (2) | US11420...)
Affinity DataKd:  180nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent