BDBM50110372 CHEMBL3605440

SMILES Cc1cc(C)c(CNC(=O)c2ccc(Oc3ccccc3)cc2)c(=O)[nH]1

InChI Key InChIKey=WEXSIZXYLPOYGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50110372   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110372(CHEMBL3605440)
Affinity DataIC50: 430nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110372(CHEMBL3605440)
Affinity DataIC50: 430nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed