BDBM50110176 CHEMBL3604460

SMILES CC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c1ccc(cc1)[N+]([O-])=O)C(=O)OC1CCCCC1

InChI Key InChIKey=SWWVFYHSSOWZMF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50110176   

LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50: 7.10E+4nMAssay Description:Non-competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of Notch1 deltaE mutant (unknown origin) expressed in HEK293 cells after 16 hrs by resazurin dye-based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of gamma secretase mediated Notch delta E activation in human HeLa cells expressing EGFP after 16 hrs by immunofluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of GST-tagged CDK2 (unknown origin) expressed in Escherichia coli in presence of Staurosporine by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed