BDBM50110104 CHEMBL162295::{4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-((S)-1-phenyl-ethyl)-amine

SMILES C[C@H](Nc1nccc(n1)-c1cc(nnc1-c1cccc(c1)C(F)(F)F)N1CCOCC1)c1ccccc1

InChI Key InChIKey=FEGPYUXSDDPKOY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50110104   

TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110104({4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110104({4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 292nMAssay Description:Inhibition of p38-related TNF-alpha release from human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110104({4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of p38-related TNF-alpha release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110104({4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JNK2-alpha-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110104({4-[6-Morpholin-4-yl-3-(3-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JNK2-alpha-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed