BDBM50110015 CHEMBL158936::N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}GLYCINAMIDE::N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-phenylmethanesulfonylamino-propionamide::US8476306, 6.1::US8476306, 6.2

SMILES NC(=N)c1ccc(CNC(=O)CNC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1

InChI Key InChIKey=MIDRZAUOYQDRRT-UHFFFAOYSA-N

Data  15 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50110015   

TargetUrokinase plasminogen activator surface receptor(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  36nM ΔG°:  -10.1kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against Plasminogen activator urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
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TargetUrokinase-type plasminogen activator(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  36nMAssay Description:In vitro inhibition of plasminogen activator urokinase after a 30 min incubation period.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  36nMAssay Description:Inhibition of urokinase-type plasminogen activator (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetUrokinase plasminogen activator surface receptor(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  120nM ΔG°:  -9.40kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against Plasminogen activator urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  150nM ΔG°:  -9.27kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetSerine protease 1(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  150nMAssay Description:In vitro inhibition of trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  290nM ΔG°:  -8.88kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetCoagulation factor X(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  3.00E+3nMAssay Description:In vitro inhibition of Coagulation factor Xa.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  1.10E+4nM ΔG°:  -6.74kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against PlasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetPlasminogen(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  1.10E+4nMAssay Description:In vitro inhibition of Plasmin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProthrombin(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  1.30E+4nM ΔG°:  -6.64kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetProthrombin(Human)
Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  1.30E+4nMAssay Description:In vitro inhibition of thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  2.80E+4nM ΔG°:  -6.19kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against PlasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent

TargetProthrombin(Rat)
The Medicines

US Patent
LigandPNGBDBM50110015(N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHY...)
Affinity DataKi:  4.20E+4nM ΔG°:  -5.95kcal/moleT: 2°CAssay Description:Inhibition constant of the compound against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2013
Entry Details
Go to US Patent