BDBM50109657 2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol-5-yl]-propionic acid::CHEMBL368858

SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccccc1O)C(O)=O

InChI Key InChIKey=VZEDUFAJDGBEHT-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109657   

TargetGlutamate receptor ionotropic, kainate 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using [3H]-kainic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataKi:  4.50E+4nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 5 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataKi:  1.25E+5nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 1 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataKi: >1.00E+6nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataKi: >1.00E+6nMAssay Description:The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 4 using established second messenger assay systems.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed