BDBM50109053 3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine::CHEMBL318738

SMILES C(CN1CCC(=CC1)c1c[nH]c2ncccc12)Oc1cccc2OCCOc12

InChI Key InChIKey=KINTWXKYQAVVRH-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109053   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109053(3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-eth...)
Affinity DataIC50: 969nMAssay Description:Antagonism at the 5-hydroxytryptamine 1A receptor in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109053(3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-eth...)
Affinity DataKi:  18nMAssay Description:Affinity for RB Serotonin transporter was determined in vitro by incubating compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109053(3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-eth...)
Affinity DataKi:  33nMAssay Description:In vitro binding affinity towards Alpha-1 adrenergic receptor was determined by the displacement of [3H]prazosinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109053(3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-eth...)
Affinity DataKi:  44nMAssay Description:In vitro binding affinity towards Human 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109053(3-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-eth...)
Affinity DataKi:  276nMAssay Description:Affinity for HC Serotonin transporter determined in vitro by incubating compound and [3H]5-HT with human carcinoma (Jar cells), previously treated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed