BDBM50109033 CHEMBL3600448

SMILES CCCc1nc(C[C@H](NC(=O)c2nccnc2N)C(=O)N2CCC[C@H]2C(N)=O)c[nH]1

InChI Key InChIKey=IHIPMQCYKZIRFV-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50109033   

TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109033(CHEMBL3600448)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109033(CHEMBL3600448)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109033(CHEMBL3600448)
Affinity DataEC50:  1.56E+3nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109033(CHEMBL3600448)
Affinity DataEC50:  120nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed