BDBM50109018 CHEMBL3601784

SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)c1cnccn1

InChI Key InChIKey=PBNFVLRTBHZJGT-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50109018   

TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109018(CHEMBL3601784)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109018(CHEMBL3601784)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109018(CHEMBL3601784)
Affinity DataEC50:  1.13E+4nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50109018(CHEMBL3601784)
Affinity DataEC50:  310nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed