BDBM50108698 1'-(2,4-difluorophenethyl)spiro[1,2,3,4-tetrahydronaphthalene-2,4'-(hexahydropyridine)]::1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[naphthalene-2(1H),4'-piperidine]::CHEMBL150210

SMILES Fc1ccc(CCN2CCC3(CC2)CCc2ccccc2C3)c(F)c1

InChI Key InChIKey=MXXYXEAKIQRROV-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50108698   

Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108698(1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108698(1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[...)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108698(1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[...)
Affinity DataKi:  69nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108698(1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[...)
Affinity DataKi:  320nMAssay Description:Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108698(1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed