BDBM50108297 CHEMBL288816::Indolocarbazole analogue

SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CSC(C)C)cc3c3c4CNC(=O)c4c4c5cc(CSC(C)C)ccc5n2c4c13

InChI Key InChIKey=SIHPNVHZKXZMMW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50108297   

TargetHigh affinity nerve growth factor receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NGF high affinity receptor tyrosine kinase TrkAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 45nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 10(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 89nMAssay Description:Inhibition of Mixed lineage kinase 2(MLK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 31nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50108297(Indolocarbazole analogue | CHEMBL288816)
Affinity DataIC50: 980nMAssay Description:Inhibition of protein kinase C (PKC) from rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed