BDBM50108052 1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxybenzene::CHEMBL46909::trans-2,4,3',5'-tetramethoxystilbene

SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1

InChI Key InChIKey=JDBCWSHYEQUBLW-UHFFFAOYSA-N

Data  1 KI  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50108052   

TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human CYP1A2 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 209nMAssay Description:Inhibition of recombinant human CYP1A1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant human CYP1B1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP1A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin) incubated for 10 mins in presence of NADPH by resorufin dye based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 4B1(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP450 in pooled human liver microsomes in presence of NADPH measured every 3 mins for 120 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP1A1 (unknown origin) expressed in HEK293-T-REx cells co-expressing POR incubated for 1 hr by resorufin dye based plate reader analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 66nMAssay Description:Inhibition of CYP1B1 (unknown origin) expressed in HEK293-T-REx cells co-expressing POR incubated for 1 hr by resorufin dye based plate reader analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetTyrosinase(Human)
Chulalongkorn University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50108052(trans-2,4,3',5'-tetramethoxystilbene | 1-[(E)-2-(3...)
Affinity DataKi:  3nMAssay Description:Inhibition of human CYP1B1 using ethoxyresorufin as substrate preincubated for 3 mins followed by NADPH addition measured after 10 mins by EROD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed