BDBM50107366 10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-5-carboxylic acid ethyl ester::CHEMBL138003

SMILES CCOC(=O)C1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=RFDCXOHZVYCSJT-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107366   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107366(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-...)
Affinity DataEC50:  126nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107366(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-...)
Affinity DataEC50:  320nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107366(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-...)
Affinity DataKi:  25nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107366(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-...)
Affinity DataKi:  966nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]progesterone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed