BDBM50107365 5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL141524

SMILES COc1cccc2OC(C3CCCCC3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=VIFBLAKPQHTSPL-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107365   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107365(5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydr...)
Affinity DataEC50:  204nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107365(5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydr...)
Affinity DataEC50:  5.00E+3nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107365(5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydr...)
Affinity DataKi:  9.90nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107365(5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydr...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]progesterone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed