BDBM50107357 10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL141836

SMILES COc1cccc2OC(C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=MAFYDXRQMZHRCV-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107357   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107357(10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-ox...)
Affinity DataEC50: >5.00E+3nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107357(10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-ox...)
Affinity DataEC50:  15nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107357(10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-ox...)
Affinity DataKi:  50nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107357(10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-ox...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]progesterone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed