BDBM50107092 (3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-dimethyl-piperazin-1-yl}-propyl)-bis-(4-fluoro-phenyl)-amine::(3-{4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-dimethyl-piperazin-1-yl}-propyl)-bis-(4-fluoro-phenyl)-amine::CHEMBL86830

SMILES C[C@@H]1CN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)C[C@@H](C)N1CCc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=YMLWABRCWIGFAK-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50107092   

TargetSigma non-opioid intracellular receptor 1(Human)
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  32.5nMAssay Description:Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  131nMAssay Description:Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  180nMAssay Description:Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  1.17E+3nMAssay Description:Binding affinity against sSigma receptor type 2 was determined by the displacement of [3H]DTG/dextrallorphan radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity at Serotonin transporter using [3H]citalopram as radioligand from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi:  4.35E+3nMAssay Description:Binding affinity against serotonin transporter by displacement of [3H]citalopram in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity at norepinephrine transporter using [3H]nisoxetine as radioligand from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50107092((3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]nisoxetine from rat brain norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed