BDBM50106185 2H-Phthalazin-1-one::CHEMBL124706

SMILES O=c1[nH]ncc2ccccc12

InChI Key InChIKey=IJAPPYDYQCXOEF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50106185   

TargetPoly [ADP-ribose] polymerase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50106185(2H-Phthalazin-1-one | CHEMBL124706)
Affinity DataIC50: 1.20E+4nMAssay Description:The compound was tested for poly(ADP-ribose)-polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50106185(2H-Phthalazin-1-one | CHEMBL124706)
Affinity DataIC50: 520nMAssay Description:Inhibition of human recombinant PDE4B2-mediated cAMP hydrolysis for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50106185(2H-Phthalazin-1-one | CHEMBL124706)
Affinity DataIC50: 5.89E+5nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50106185(2H-Phthalazin-1-one | CHEMBL124706)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed