BDBM50106026 (S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid hydroxyamide::CHEMBL318484

SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(Oc2cccnc2)cc1

InChI Key InChIKey=YTRMRJDVKQXSIU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50106026   

LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 8.60E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 5.70nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 0.0480nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 7.90nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 7.94nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed