BDBM50105922 CHEMBL3598041

SMILES [2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(cc1OCC(F)(F)F)-c1cnn(C)c1C(C)C

InChI Key InChIKey=ZZHULZAEOZXKFZ-HPRDVNIFSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105922   

TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105922(CHEMBL3598041)
Affinity DataIC50: 38nMAssay Description:Binding affinity to GST-tagged RORgamma LBD (unknown origin) assessed as inhibition of interaction with co-activatior peptide TRAP220 preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105922(CHEMBL3598041)
Affinity DataEC50:  160nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) transfected in HEK293T cells after 16 to 20 hrs by GAL4 luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Biogen

Curated by ChEMBL
LigandPNGBDBM50105922(CHEMBL3598041)
Affinity DataEC50:  818nMAssay Description:Inverse agonist activity at RORgamma in C57BL/6 mouse splenocytes assessed as reduction of IL-17 production after 2 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed