BDBM50105695 (E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-methyl-acrylamide::3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-methyl-acrylamide::CHEMBL100035::N-hydroxy-2-methyl-3-(4-(phenylsulfonamido)phenyl)acrylamide::US8796330, 91

SMILES C\C(=C/c1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO

InChI Key InChIKey=RCHSCTGFXSOIJV-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50105695   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105695(US8796330, 91 | CHEMBL100035 | N-hydroxy-2-methyl-...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105695(US8796330, 91 | CHEMBL100035 | N-hydroxy-2-methyl-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50105695(US8796330, 91 | CHEMBL100035 | N-hydroxy-2-methyl-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105695(US8796330, 91 | CHEMBL100035 | N-hydroxy-2-methyl-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105695(US8796330, 91 | CHEMBL100035 | N-hydroxy-2-methyl-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed