BDBM50105694 4-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-butyramide::CHEMBL97860::N-hydroxy-4-(4-(phenylsulfonamido)phenyl)butanamide::US8796330, 42

SMILES ONC(=O)CCCc1ccc(NS(=O)(=O)c2ccccc2)cc1

InChI Key InChIKey=KJRQLODJJCERFP-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50105694   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataEC50: >2.50E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM50105694(US8796330, 42 | N-hydroxy-4-(4-(phenylsulfonamido)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Homo sapiens (human) HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article