BDBM50105691 (E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acrylamide::3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acrylamide::CHEMBL317814::N-hydroxy-3-(4-(phenylsulfonamido)phenyl)acrylamide::US8796330, 36

SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccccc2)cc1

InChI Key InChIKey=XPHVJIKSPLGZRT-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50105691   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataIC50: 200nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataIC50: 200nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM50105691(CHEMBL317814 | US8796330, 36 | N-hydroxy-3-(4-(phe...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Homo sapiens (human) HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article