BDBM50105679 (E)-N-Hydroxy-3-[4-(4-nitro-benzenesulfonylamino)-phenyl]-acrylamide::CHEMBL95680::US8796330, 89

SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)cc1

InChI Key InChIKey=IKLORKBSKYBOFG-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105679   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105679(CHEMBL95680 | US8796330, 89 | (E)-N-Hydroxy-3-[4-(...)
Affinity DataIC50: 900nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105679(CHEMBL95680 | US8796330, 89 | (E)-N-Hydroxy-3-[4-(...)
Affinity DataEC50:  2.00E+4nMAssay Description:Concentration of compound required for acetylation of histone-4 in human T24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50105679(CHEMBL95680 | US8796330, 89 | (E)-N-Hydroxy-3-[4-(...)
Affinity DataIC50: 700nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed