BDBM50105330 CHEMBL1851943

SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC

InChI Key InChIKey=JHDKZFFAIZKUCU-UHFFFAOYSA-N

Data  11 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50105330   

TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length HDAC11 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as substrate measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 82nMAssay Description:Inhibition of N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 2.84E+3nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC class2a as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 5.11E+3nMAssay Description:Inhibition of HDAC5 (unknown origin) using fluorogenic HDAC class2a as substrate measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 (627 to 1084 end residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC3 (1 to 428 end residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residue...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic HDAC substrate 3 incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 50nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 end residues) expressed in baculovirus infected Sf9 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 140nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 126nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  16nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  19nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  21nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  23nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  24nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  27nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  28nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  43nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  48nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  107nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
A*Star

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  247nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed