BDBM50105310 CHEMBL3597786

SMILES Fc1cc(Br)cc(c1)[C@@H]1C[C@H](c2cccc(Br)c2)n2nnnc2N1

InChI Key InChIKey=KYKKWYKMGWBEJU-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50105310   

TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataKd:  23nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataIC50: 43nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataIC50: 1.45E+7nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HIF-2alpha in human Hep3B cells assessed as downregulation of EPO mRNA expression by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to His6-Gbeta1-fused HIF-2alpha PAS-B domain S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105310(CHEMBL3597786)
Affinity DataKd: >5.00E+3nMAssay Description:Binding affinity to wild type GST-fused HIF-1alpha PAS-B domain (238 to 349) (unknown origin) expressed in Escherichia coli assessed as compound-prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed