BDBM50105276 CHEMBL3597698

SMILES c1cc(cc(c1)Br)[C@@H]2C[C@@H](n3c(nnn3)N2)c4cccc(c4)Br

InChI Key InChIKey=JHRYBPMSBXHLJL-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50105276   

TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataKd:  63nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataIC50: 112nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)