BDBM50103860 2-{[2-(5-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-methyl-3H-benzoimidazole-5-carbonyl]-amino}-3-phosphono-propionic acid::2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-methyl-3H-benzoimidazole-5-carbonyl]-amino}-3-phosphono-propionic acid::CHEMBL421708

SMILES Cn1c(Cc2nc3ccc(cc3[nH]2)C(N)=O)nc2ccc(cc12)C(=O)NC(CP(O)(O)=O)C(O)=O

InChI Key InChIKey=PEXFKSJDXSBOLP-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50103860   

TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataIC50: 1.67E+5nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease in the absence of Zn2+More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease in the presence of Zn2+.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataKi:  27nMAssay Description:Inhibition of HCV NS3/4a protease in presence Zn2+More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataKi:  200nMAssay Description:Inhibition of HCV serine protease NS3/NS4A in the presence of ZnMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataKi:  200nMAssay Description:Inhibition of Hepatitis C virus NS3/NS4A proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of HCV NS3/4a proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50103860(2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed