BDBM50103571 CHEMBL3335793

SMILES CC(C)n1c2sc(Cc3c(C)[nH]nc3C(F)(F)F)c(C(=O)N3C[C@](C)(O)CO3)c2c(=O)n(C)c1=O

InChI Key InChIKey=PRNXOFBDXNTIFG-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50103571   

TargetMonocarboxylate transporter 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to MCT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human MCT4 in human MDA-MB-231 cells assessed as inhibition of radioactive lactate efflux preincubated for 30 mins followed by D(+)gluc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human MCT4 in human SNU-398 cells assessed as inhibition of radioactive lactate efflux preincubated for 30 mins followed by D(+)glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 4(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataIC50: 22nMAssay Description:Inhibition of human MCT4 in human SNU-398 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataKi:  2nMAssay Description:Binding affinity to MCT1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 2(Human)
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management

Curated by ChEMBL
LigandPNGBDBM50103571(CHEMBL3335793)
Affinity DataKi:  20nMAssay Description:Binding affinity to MCT2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed