BDBM50103451 CHEMBL3398252

SMILES O\C(=C/C(=O)c1cc(Cc2cc(F)cc(F)c2)cn(Cc2ccccc2F)c1=O)C(=O)N1CCN(CC1)c1ccc(cc1)-n1cccc1

InChI Key InChIKey=FVQZBYCHVJMDDI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50103451   

TargetCytochrome P450 2D6(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of CYP3D6 in pooled mixed-gender human liver microsomes using dextromethorphan substrate in presence of NADPH pre-incubated for 3 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of CYP3A4 in pooled mixed-gender human liver microsomes using triazolam substrate in presence of NADPH pre-incubated for 3 mins by HPLC-UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled mixed-gender human liver microsomes using testosterone substrate in presence of NADPH pre-incubated for 3 mins by HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 2B7(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of of UGT3B7 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A9(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of of UGT1A9 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1-6(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of of UGT1A6 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
University of Georgia

Curated by ChEMBL
LigandPNGBDBM50103451(CHEMBL3398252)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of of UGT1A1 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed