BDBM50103336 4-[5-({(3-Amino-propyl)-[1-(3-chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-amino}-methyl)-imidazol-1-ylmethyl]-benzonitrile::CHEMBL98147

SMILES NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2cccc(Cl)c2)C1=O

InChI Key InChIKey=CDXIZXQBISVZMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103336   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103336(4-[5-({(3-Amino-propyl)-[1-(3-chloro-benzyl)-2-oxo...)
Affinity DataIC50: 7.5nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103336(4-[5-({(3-Amino-propyl)-[1-(3-chloro-benzyl)-2-oxo...)
Affinity DataIC50: 150nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103336(4-[5-({(3-Amino-propyl)-[1-(3-chloro-benzyl)-2-oxo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed