BDBM50103247 10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL95644

SMILES COc1cccc2OC(c3cccc(c3)C(F)(F)F)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=AZKXBAPRQCXHRZ-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50103247   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataKi:  11nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 32nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 44nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 57nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 105nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataKi:  493nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataKi:  3.36E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed