BDBM50101928 17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide::CHEMBL52610

SMILES O=C1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4cccc(NC(=O)[C@@H](Cc5ccccc5)N1)c4c3)c2

InChI Key InChIKey=QGCNWBQUPNGUPL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50101928   

LigandPNGBDBM50101928(17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101928(17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101928(17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 310nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed