BDBM50101913 18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide::CHEMBL53183

SMILES CN1c2cccc3ccc(Oc4cc(Cn5cncc5CNCC1=O)ccc4C#N)cc23

InChI Key InChIKey=MIUVLTBXZYHORO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50101913   

LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 55nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 6.72E+3nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed