BDBM50101792 CHEMBL3394942

SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4ccc(cc34)C(F)(F)F)CCn2c1=O

InChI Key InChIKey=HGFAJEPTMZEYKW-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101792   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50101792(CHEMBL3394942)Copy SMILESCopy InChI

Affinity DataIC50: 22nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2016
Entry Details Article
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