BDBM50101747 CHEMBL3394946

SMILES C[C@H](N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1cn(C)c2ccc(cc12)C(F)(F)F

InChI Key InChIKey=UILXLQNRZWNXLV-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101747   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50101747(CHEMBL3394946)Copy SMILESCopy InChI

Affinity DataIC50: 6nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL