BDBM50101661 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethylamino}-2-methyl-6-phenyl-2H-pyridazin-3-one::CHEMBL311479

SMILES COc1ccccc1N1CCN(CCNc2cc(nn(C)c2=O)-c2ccccc2)CC1

InChI Key InChIKey=CYGUSDVXGIEDMH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50101661   

TargetAlpha-1A adrenergic receptor(Human)
Istituto Chimico Farmaceutico E Tossicologico

Curated by ChEMBL
LigandPNGBDBM50101661(4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethylam...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity towards human cloned alpha-1A-adrenoceptor using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Istituto Chimico Farmaceutico E Tossicologico

Curated by ChEMBL
LigandPNGBDBM50101661(4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethylam...)
Affinity DataKi:  2.01nMAssay Description:Binding affinity towards human cloned alpha-1B-adrenoceptor using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Istituto Chimico Farmaceutico E Tossicologico

Curated by ChEMBL
LigandPNGBDBM50101661(4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethylam...)
Affinity DataKi:  11.8nMAssay Description:Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Istituto Chimico Farmaceutico E Tossicologico

Curated by ChEMBL
LigandPNGBDBM50101661(4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethylam...)
Affinity DataKi:  14.0nMAssay Description:Binding affinity towards human cloned 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed