BDBM50101635 2,4-Diamino-quinazoline-6-carboxylic acid benzyl ester::CHEMBL306731::i2,4-Diamino-quinazoline-6-carboxylic acid benzyl ester

SMILES Nc1nc(N)c2cc(ccc2n1)C(=O)OCc1ccccc1

InChI Key InChIKey=KJKDXBKWHQYTKA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50101635   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50101635(i2,4-Diamino-quinazoline-6-carboxylic acid benzyl ...)
Affinity DataIC50: 360nMAssay Description:Inhibitory concentration against dihydrofolate reductase DHFR from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50101635(i2,4-Diamino-quinazoline-6-carboxylic acid benzyl ...)
Affinity DataIC50: 420nMAssay Description:Inhibitory concentration against dihydrofolate reductase DHFR from rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50101635(i2,4-Diamino-quinazoline-6-carboxylic acid benzyl ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against dihydrofolate reductase dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50101635(i2,4-Diamino-quinazoline-6-carboxylic acid benzyl ...)
Affinity DataIC50: 420nMAssay Description:Inhibition of rat liver Dihydrofolate reductase (rlDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed