BDBM50101514 (R)-N*1*-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4*-hydroxy-2-phenethyl-succinamide::CHEMBL77808::N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4*-hydroxy-2-phenethyl-succinamide

SMILES ONC(=O)C[C@@H](CCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)NCCc1ccccc1

InChI Key InChIKey=FCKWIYZMPDIGLV-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50101514   

Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of the gelatinase-A enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  2.24nMAssay Description:Inhibitory constant against matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  77nMAssay Description:Inhibitory constant against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  77nMAssay Description:Inhibition of the stromelysin enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetInterstitial collagenase(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  618nMAssay Description:Inhibitory constant against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50101514(N*1*-(2-Cyclohexyl-1-phenethylcarbamoyl-ethyl)-N*4...)
Affinity DataKi:  618nMAssay Description:Inhibition of the collagenase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article