BDBM50100662 CHEMBL553371::CHEMBL77971::methyl 2-(4-aminophenyl)-1-oxo-7-(2-pyridylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3-isoquinolinecarboxylate.dihydrochloride

SMILES COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)cc2c(=O)n1-c1ccc(N)cc1

InChI Key InChIKey=ORZROTLRYOYVPB-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50100662   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Dog)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against rat heart Phosphodiesterase 1(PDE1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Dog)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of canine lung Phosphodiesterase 4 (PDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataEC50:  7.90nMAssay Description:Relaxant effect on isolated rabbit corpus cavernosumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Bovine)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibitory activity against phosphodiesterase-2 (PDE2) isolated from bovine adrenal glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Bovine)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of bovine adrenal gland Phosphodiesterase 2 (PDE2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bovine)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Phosphodiesterase 6 isolated from bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase-3 (PDE3) isolated from canine heartMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against phosphodiesterase 4 (PDE4) isolated from canine lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50100662(CHEMBL77971 | CHEMBL553371 | methyl 2-(4-aminophen...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase-1 (PDE1) isolated from canine lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed