BDBM50100300 2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22659

SMILES Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1

InChI Key InChIKey=JRTOBKVVIBBEQD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100300   

LigandPNGBDBM50100300(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rate of incorporation of [3H]FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50100300(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Affinity DataIC50: 96nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50100300(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Affinity DataIC50: 23nMAssay Description:Inhibition of rate of incorporation of [3H]GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-trans...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed