BDBM50099304 CHEMBL275541::[(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3-yl]-thiophen-2-yl-methanone

SMILES CN1C[C@H]([C@@H](C1)c1ccc(Cl)cc1)C(=O)c1cccs1

InChI Key InChIKey=DQDLEPZVHJFUCX-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50099304   

TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataIC50: 46nMAssay Description:Functional cocaine antagonism was evaluated by inhibition of [3H]dopamine reuptake at a concentration of 30 nM with cocaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataIC50: 641nMAssay Description:Functional cocaine antagonism was evaluated by inhibition of [3H]dopamine reuptake at a concentration of 100 nM with cocaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataIC50: 308nMAssay Description:Functional cocaine antagonism was evaluated by inhibition of [3H]dopamine reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataKi:  31nMAssay Description:Inhibition of [3H]NE uptake at Norepinephrine transporter in rat parietal/occipital cortex was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataKi:  200nMAssay Description:Inhibition of [3H]DA uptake at Dopamine transporter in rat cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099304([(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-pyrrolidin-3...)
Affinity DataKi:  230nMAssay Description:Inhibition of [3H]5-HT uptake at Serotonin transporter in rat mid brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed