BDBM50099296 (3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester::4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester::CHEMBL297166

SMILES COC(=O)[C@@H]1CN(C)CC[C@H]1c1ccc(Cl)cc1

InChI Key InChIKey=GDFVYUDIAQQDTA-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50099296   

TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataIC50: 1.36E+3nMAssay Description:Ability to displace [3H]WIN-35428 binding to dopamine transporter from rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataIC50: 5.09E+3nMAssay Description:Inhibition of high-affinity uptake of [3H]dopamine at dopamine transporter into rat striatal nerve endings (synaptosomes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  242nMAssay Description:Ability to inhibit high affinity uptake of norepinephrine transporter into the nerve endings of rat synaptosomes using [3H]NE radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  396nMAssay Description:Evaluated for ability to inhibit high affinity uptake of [3H]-NE using rat nerve endings obtained from brain regions enriched in Norepinephrine trans...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  930nMAssay Description:Displacement of [3H]5-HT from serotonin transporter of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]mazindol binding to dopamine transporter (DAT) in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  2.01E+3nMAssay Description:Displacement of [3H]WIN-35248 from dopamine transporter (DAT) of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  2.89E+3nMAssay Description:Inhibition of high affinity DA uptake into rat synaptosomes using [3H]DAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  2.93E+3nMAssay Description:Displacement of [3H]WIN-35248 from dopamine transporter (DAT) of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296(4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxyl...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of high affinity serotonin uptake into rat synaptosomes using [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed