BDBM50097938 3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutanol::CHEMBL168266

SMILES Nc1ncnc2n(cc(-c3ccccc3)c12)C1CC(O)C1

InChI Key InChIKey=PTOVCSIEMQUGPX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50097938   

TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097938(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p60 c-Src tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097938(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097938(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097938(3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of v-Abl tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed