BDBM50097936 7-Cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL166766

SMILES Nc1ncnc2n(cc(-c3ccccc3)c12)C1CCC1

InChI Key InChIKey=OVPLBDSXFCRGJY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50097936   

TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097936(7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p60 c-Src tyrosine kinase mediated phosphorylation of Fak in IC8.1 fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097936(7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 730nMAssay Description:Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50097936(7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097936(7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 110nMAssay Description:Inhibition of p60 c-Src tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097936(7-cyclobutyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 90nMAssay Description:Inhibition of v-Abl tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed