BDBM50097363 1-((1H-imidazol-1-yl)methyl)-4-nitro-9H-xanthen-9-one::1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one::CHEMBL307160

SMILES [O-][N+](=O)c1ccc(Cn2ccnc2)c2c1oc1ccccc1c2=O

InChI Key InChIKey=VKGUMSNSPMTJMS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50097363   

TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 970nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human testicular microsome Steroid 17-alpha-hydroxylase/17,20 lyaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 970nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 970nMAssay Description:Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed