BDBM50097219 C-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-methylamine::CHEMBL44819::US8629135, SW-08

SMILES NCC1c2ccccc2CCc2ccccc12

InChI Key InChIKey=YJCNPACNIAQKNY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50097219   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Queen'S University At Kingston

US Patent
LigandPNGBDBM50097219(US8629135, SW-08 | CHEMBL44819 | C-(10,11-Dihydro-...)
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097219(US8629135, SW-08 | CHEMBL44819 | C-(10,11-Dihydro-...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor sites by using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097219(US8629135, SW-08 | CHEMBL44819 | C-(10,11-Dihydro-...)
Affinity DataKi:  112nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50097219(US8629135, SW-08 | CHEMBL44819 | C-(10,11-Dihydro-...)
Affinity DataKi:  112nMAssay Description:Binding affinity was performed using [3H]ketanserin as the radioligand and stably transfected NIH3T3 cells expressing the 5-hydroxytryptamine 2A rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed