BDBM50096215 CHEMBL3593815

SMILES Cc1ccc(CNC(=O)c2cc(cnc2NCc2ccc3OCOc3c2)C#CC(C)(C)O)cc1C(F)F

InChI Key InChIKey=RNZLZCFOXVJREL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50096215   

TargetGrowth hormone secretagogue receptor type 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50: 0.440nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50: 5.40nMAssay Description:Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed