BDBM50095554 4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL344545

SMILES COc1ccc(cc1)S(=O)(=O)N1C[C@H](C[C@@H]1C(=O)NO)N1CCCS1(=O)=O

InChI Key InChIKey=WIWASQOQNPNFMY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095554   

TargetMatrilysin(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095554(4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-7 (matrilysin, MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095554(4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-...)
Affinity DataIC50: 42nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -1 (collagenase-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095554(4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -3 (stromelysin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095554(4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-...)
Affinity DataIC50: 0.400nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloprotease-13 (collagenase-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed