BDBM50095540 4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide::CHEMBL148120

SMILES CCCN([C@H]1C[C@@H](N(C1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO)C(=O)[C@@H](O)CCc1ccccc1

InChI Key InChIKey=PTGMPWHDIULCAR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50095540   

Target72 kDa type IV collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -2 (gelatinase-A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50: 260nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -1 (collagenase-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against matrix metalloprotease -3 (stromelysin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of matrix metalloprotease-13 (collagenase-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed